After a wild night out, a teenage girl (Anna Attanasio) is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction, leading Cameron to believe that she may have been drugged by roofies and raped by a comic book creator (Marcus Giamatti) she was following. They first give her flumazenil to antagonize the effect, but later intentionally drug her with amobarbital to make her tell the truth about the night.



Meanwhile, Cuddy, Wilson and House spend a weekend away from the hospital to attend a medical conference. Wilson feels remorse after having performed euthanasia on a terminally ill cancer patient by intentionally having told the sequence to the patient's PCA machine to a coworker loud enough for the patient himself to hear, availing him to administer himself a morphine overdose. Wilson plans to give a speech about the incident, although it may sever his career, but House drugs Wilson and takes his speech during the convention in another person's name. Later, Wilson admits that it was irrational to sacrifice his career because of his remorse.



After the convention, House finds that Cuddy is dating the private investigator Lucas (Michael Weston), who takes care for the baby which a babysitter was supposedly taking care of. House is told by Wilson he isn't reliable because he drugged him.



Towards the end of the episode, Chase confesses to Cameron that he killed Dibala. The episode ends as Cameron lies in shock of what she hears.